Crystal structure of Fab WN1 222-5 in complex with LPS

Crystal structure of Fab WN1 222-5 in complex with LPS Descriptor: 2-amino-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-[alpha-D-galactopyranose-(1-6)]alpha-D-glucopyranose-(1-3)-[L-glycero-alpha-D-manno-heptopyranose-(1-7)]4-O-phosphono-L-glycero-alpha-D-manno-heptopyranose-(1-3)-4-O-phosphono-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, SULFATE ION, WN1 222-5 Fab (IgG2a) heavy chain, ... Authors: Gomery, K, Evans, S.V. Deposit date: 2011-12-08 Release date: 2012-12-05 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS. Proc.Natl.Acad.Sci.USA, 109, 2012

与脂多糖（Lipopolysaccharide, LPS）结合的Fab WN1 222-5晶体结构。配体结构描述符：2-氨基-2-脱氧-α-D-吡喃葡萄糖-(1→2)-α-D-吡喃葡萄糖-(1→2)-α-D-吡喃葡萄糖-(1→3)-[α-D-半乳糖吡喃糖-(1→6)]α-D-吡喃葡萄糖-(1→3)-[L-甘油-α-D-甘露-庚吡喃糖-(1→7)]4-O-膦酰基-L-甘油-α-D-甘露-庚吡喃糖-(1→3)-4-O-膦酰基-L-甘油-α-D-甘露-庚吡喃糖-(1→5)-[3-脱氧-α-D-甘露-辛-2-吡喃糖醛酸-(2→4)]3-脱氧-α-D-甘露-辛-2-吡喃糖醛酸；体系包含硫酸根离子、WN1 222-5 Fab（IgG2a）重链等组分。作者：Gomery, K、Evans, S.V.；沉积日期：2011-12-08；发布日期：2012-12-05；最后修改日期：2024-11-27；实验方法：X射线衍射（分辨率1.73 Å）；引用文献：抗体WN1 222-5在脂多糖识别过程中模拟Toll样受体4（Toll-like receptor 4）的结合行为，《美国国家科学院院刊》，109卷，2012年