Chromatin insulators are DNA-protein complexes situated throughout the genome that contribute to higher order organization and demarcation into distinct transcriptional domains. Mounting evidence in

NIAID Data Ecosystem50

Iron-sensitive RNA regulation by poly C binding proteins [DKD_RNASeq]

铁代谢调控

RNA结合蛋白功能

Iron is important for normal cellular function and posttranscriptional mechanisms regulate the cellular response to iron deficiency. In this study we explore how RNA binding proteins, PCBP1 and PCBP2,

NIAID Data Ecosystem20

Quantifying RNA-Protein Interactions Characterizes Recurrent Mutationsin RNA Binding Proteins in Cancer. Quantifying RNA-Protein Interactions Characterizes Recurrent Mutationsin RNA Binding Proteins in Cancer

RNA结合蛋白功能

癌症突变机制研究

Quantitative criteria to identify proteins as RNA-binding proteins (RBPs) are presently lacking, as are criteria to define RBP target RNAs. Here, we develop an ultraviolet (UV) cross-linking immunopre

NIAID Data Ecosystem50

4SU-iCLIP of MATR3 from HEK293 cells with or without PTBP1 depletion. 4SU-iCLIP of MATR3 from HEK293 cells with or without PTBP1 depletion

RNA结合蛋白功能

蛋白质-RNA相互作用

The aim of the experiment was to compare binding of MATR3 in presence and absence of PTBP1. HEK293T cells were transfected with siRNA targeting PTBP1 and PTBP2 or control sequences and labelled with 4

NIAID Data Ecosystem30

Pathways and gene sets enriched in RBM10-only RIP-Seq targets.

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