Total synthesis of lissodendoric acid A via stereospecific trapping of a strained cyclic allene

This data set includes FID files for NMR spectra obtained during the course of our study of the total synthesis of lissodendoric acid A. Lissodendoric acid A is manzamine alkaloid, with a complex structure. Our concise total synthesis hinges on the development of a regioselective, diastereoselective, and stereospecific trapping of a fleeting cyclic allene intermediate. This key step swiftly assembles the azadecalin framework of the natural product, allows for a succinct synthetic endgame, and enables a 12-step total synthesis. These studies demonstrate that strained cyclic allenes are versatile building blocks in chemical synthesis. The data set includes both proton and carbon NMR FID files for all synthetic intermediates. The files may be reused., , The FID files can be opened using Bruker's TopSpin software (free for academic users). Other free software can also be utilized to process FID files, such as VnmrJ, SpinWorks, NMRPipe, matNMR 3, or iNMR.本数据集包含我们在研究利斯树精酸A（lissodendoric acid A）全合成过程中获取的核磁共振（Nuclear Magnetic Resonance, NMR）谱自由衰减信号（Free Induction Decay, FID）文件。利斯树精酸A属于马扎因生物碱（manzamine alkaloid），结构复杂。我们的简洁全合成路线核心在于开发了一种区域选择性、非对映选择性且立体专一性的瞬态环联烯中间体捕获策略。该关键步骤可快速构建该天然产物的氮杂十氢化萘（azadecalin）骨架，为合成收尾阶段提供了简洁路径，并实现了仅需12步的全合成。本研究证实，张力环联烯是化学合成中用途广泛的合成砌块。本数据集涵盖所有合成中间体的氢谱与碳谱自由衰减信号文件，此类文件可重复使用。此类FID文件可通过布鲁克（Bruker）的TopSpin软件打开（学术用户可免费使用该软件），也可借助其他免费软件处理，例如VnmrJ、SpinWorks、NMRPipe、matNMR 3及iNMR。