Mus musculus Raw sequence reads. Mus musculus

Exposure to environmental factors during fetal development lead epigenome modifications in fetal germ cells to alter gene expression and promotes diseases in successive generations. Maternal exposure to Di -(2-ethylhexyl) phthalate (DEHP), a plasticizer widely used for the manufacturing of consumer products, induces defects in spermatogenesis in successive generations in mouse, but mechanisms of impaired spermatogenesis are unknown. Here we showed DNA hyper-methylation of promoters in spermatogenesis-related genes by maternal DEHP exposure in fetal and testicular germ cells.