Enantioselective C–H Functionalization–Addition Sequence Delivers Densely Substituted 3‑Azabicyclo[3.1.0]hexanes
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https://figshare.com/articles/dataset/Enantioselective_C_H_Functionalization_Addition_Sequence_Delivers_Densely_Substituted_3_Aza_bicyclo_3_1_0_hexanes/5368663
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资源简介：
An
enantioselective C–H functionalization route to perfluoroalkyl-containing
3-azabicyclo[3.1.0]hexanes is disclosed. A modular
and bench-stable diazaphospholane ligand enables highly enantioselective
Pd(0)-catalyzed cyclopropane C–H functionalization using trifluoroacetimidoyl
chlorides as electrophilic partners. In turn, the resulting cyclic
ketimine products react smoothly with a broad variety of nucleophiles
in one-pot processes enabling the rapid and modular construction of
heavily substituted pyrrolidines.
创建时间：
2017-09-01
