Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid,
We have previously isolated a murine erythroleukemia cell line refractive to re-enter a cell differentiation program as opposite to the progenitor cell line. We use RNA-seq to identify differentially
Two Ewing's sarcoma cell lines were evolved in the standard chemotherapy treatment given to patients. After each dose of chemotherapy treatment, drug sensitivity profiles were captured on each cell li
