Targeted sequencing reveals candidate causal variants for dairy bull subfertility

We previously identified five genomic regions, located on BTA8 (72.2 Mb), BTA9 (43.7 Mb), BTA13 (60.2 Mb), BTA17 (63.3 Mb), and BTA27 (34.7 Mb), that show very significant dominance effects on bull fertility (Nani et al. BMC Genomics, 2019). Each of these regions explains about 5-8% of the observed differences in sire conception rate between Holstein bulls. Here, we aimed to identify the causal variants responsible for this variation using targeted sequencing (10Mb per region).