Mediator complex subunit 12 (MED12), a key component of RNA polymerase II transcriptional complex, is frequently mutated in human tumors, yet little is known about how it controls tumor progression. H
Cell proliferation is a fundamental characteristic of organisms, driven by the holistic functions of multiple proteins encoded in the genome. However, the individual contributions of thousands of gene
RBM39 is an essential component of the spliceosome, playing a critical role in maintaining mRNA integrity. Its depletion significantly exacerbates RNA splicing defects and demonstrates potent anticanc
