Inflammatory Response in White Adipose Tissue in the Non-Obese Hormone-Sensitive Lipase Null Mouse Model

In the present study, a local inflammatory response in white adipose tissue from the nonobese HSL-null mouse model is demonstrated. The protein levels of several well-known markers of inflammation, like TNFα and ferritin HC, were highly increased and accompanied by an activation of NFκB. A number of macrophage proteins, i.e., gal-3, Capg, and MCP-4, were expressed at increased levels and immunohistochemical analyses revealed an increased infiltration of F4/80+ cells.Keywords: hormone-sensitive lipase • white adipose tissue • proteomics • retinoic acid • inflammation