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Genotoxic alterations of cord blood cells in newborns exposed in utero to a zidovudine-based antiretroviral combination

ChEBI2012-05-02 更新2026-07-21 收录

母婴HIV治疗安全性

药物遗传毒性评估

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-37748 数据链接链接失效反馈

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资源简介：

Genotoxic alterations of cord blood cells in newborns exposed in utero to a zidovudine-based antiretroviral combination

应用场景：

创建时间：

2012-05-02

药物遗传毒性评估

癌症风险生物标志物

Genome instability is a hallmark of most human cancers and is exacerbated following cellular exposure to exogenous/endogenous chemicals that can promote replication stress, activation of low-fidelity

NIAID Data Ecosystem40

Evaluation of anticytotoxic and antigenotoxic activities in the bone marrow of mice treated with sulfonamide chalcone N-{4-[3-(4-nitrophenyl)prop-2-enoyl]phenyl}-benzenesulfonamide (CPN) plus mitomycin C (MMC) based on MNPCE and PCE/NCE frequency.

药物遗传毒性评估

小鼠骨髓

1 Negative control: dimethylsulfoxide (DMSO) 0.1 mL/10 g body weight (b.w.) 2 Positive control: mitomycin C (MMC) 4 mg/kg (80% LD50). All values are mean ± SD of five mice. 3 Statistical analysis: one

NIAID Data Ecosystem20

Data to Accompany: Supra-Exponentiating US Trend-breaking Cannabinoid Driven Atrial Septal Defect Trajectories as Key Epidemiological Bellweather Indices of Widespread Cannabinoid Genotoxicity

药物遗传毒性评估

先天性心脏病

Raw Data and analysis Code for the data to the paper

Mendeley Data10

Number of breaks per cell in cultured lymphocytes from FA patients.

染色体断裂

药物遗传毒性评估

The effect of the Vorinostat was calculated by the percentage of reduction of the number of breaks per cell in the Vorinostat treatments relatively to Spontaneous breaks and DEB. Number of breaks per

NIAID Data Ecosystem30

Dominant lethal assay (DLA) after males were treated with Zidovudine or Nevirapine for four weeks.

生殖毒理学

药物遗传毒性评估

DLA simulates when the “father-only” is ARV treated. EMS = Ethylmethylsulfonate (one-time dose); ZDV = Zidovudine; NVP = Nevirapine. aNumber of pregnancies observed after 1∶1 mating. bNumber of pregna

NIAID Data Ecosystem20

Genotoxic alterations of cord blood cells in newborns exposed in utero to a zidovudine-based antiretroviral combination

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