Adverse Outcome Pathway on aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX‑2
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This AOP details the linkage between activation of the aryl hydrocarbon receptor (AhR) and early life stage mortality in oviparous vertebrates. It can be initiated mostly by dioxin-like compounds, which are able to bind to the AhR causing heterodimerisation with the aryl hydrocarbon nuclear translocator (ARNT) and interaction with...
