Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase with Tetrahydrofurfurylamine

Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase with Tetrahydrofurfurylamine Descriptor: 1-[(2R)-oxolan-2-yl]methanamine, Cholinephosphate cytidylyltransferase, Guanidinium Authors: Duclovel, C, Gelin, M, Krimm, I, Cerdan, R, Guichou, J.-F. Deposit date: 2021-10-25 Release date: 2022-11-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design of PfCCT inhibitors To Be Published

恶性疟原虫（Plasmodium falciparum）CTP：磷酸胆碱胞苷酰转移酶（CTP:phosphocholine cytidylyltransferase）结合四氢糠胺（Tetrahydrofurfurylamine）的C端催化结构域晶体结构，配体标识为：1-[(2R)-四氢呋喃-2-基]甲胺、胆碱磷酸胞苷酰转移酶、胍（Guanidinium）。
作者：Duclovel C、Gelin M、Krimm I、Cerdan R、Guichou J.-F.
入库日期：2021-10-25
发布日期：2022-11-09
最后修改日期：2024-01-31
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.87埃（Å）
引用文献：《利用超低分子量配体开展晶体筛选以指导PfCCT抑制剂的药物研发》，待发表。