Predictions for South Africa generated from our transmission model if universal access to treatment is achieved (black curves) or a universal T&T (with annual testing) strategy (blue curves) is implemented.

The dynamics of acquired and transmitted drug resistance are not included in these simulations. Solid lines denote the case where the treatment-induced reduction in infectivity is 96% and dashed lines denote the case where the reduction is 85%. Panels show (A) annual incidence over time, (B) number of infections prevented over time and (C) number of individuals in need of treatment over time.