A Bayesian segmentation of the amygdala in ALS and PLS: volumetric data

Temporal lobe degeneration is a recognised feature of motor neuron disease which may manifest in a range of cognitive deficits contributing to the clinical heterogeneity of the condition. Computational neuroimaging allows the detailed characterisation of this region in vivo, but existing neuroimaging studies have invariably evaluated the amygdala as a single structure. In this data set we present the volumetric profile of specific amygdalar nuclei in 100 patients with ALS, 33 patients with PLS and 117 healthy controls. T1-weighted images were acquired with a 3D Inversion Recovery prepared Spoiled Gradient Recalled echo pulse sequence with an isometric spatial resolution of 1 mm3 on a 3 Tesla MRI system. A Bayesian inference was used to segment the amygdala into specific nuclei using a probabilistic atlas. The study was sponsored by the Spastic Paraplegia Foundation, Inc. (SPF), the Health Research Board (HRB EIA-2017-019), the EU Joint Programme – Neurodegenerative Disease Research (JPND), the Andrew Lydon scholarship, the Irish Institute of Clinical Neuroscience (IICN), the Iris O'Brien Foundation. Methodological details are provided in: Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis. Chipika RH, Christidi F, Finegan E, Li Hi Shing S, McKenna MC, Chang KM, Karavasilis E, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, Bede P. J Neurol Sci. 2020 Jul 18:117039. doi: 10.1016/j.jns.2020.117039. Online ahead of print. PMID: 32713609颞叶变性是运动神经元病的公认特征，可表现出一系列认知功能缺损，进而加剧该疾病的临床异质性。计算神经影像学可实现该脑区的活体详细特征刻画，但现有神经影像学研究均仅将杏仁核作为单一结构进行评估。本数据集提供了100例肌萎缩侧索硬化（amyotrophic lateral sclerosis, ALS）患者、33例原发性侧索硬化（primary lateral sclerosis, PLS）患者以及117例健康对照者的特定杏仁核亚核体积特征。本研究采用3特斯拉MRI系统，通过3D反转恢复准备的扰相梯度回波脉冲序列采集T1加权成像（T1-weighted images），其空间分辨率为1 mm³的各向同性体素。本研究采用概率图谱结合贝叶斯推断（Bayesian inference）将杏仁核分割为特定亚核。本研究由痉挛性截瘫基金会（Spastic Paraplegia Foundation, Inc., SPF）、健康研究委员会（Health Research Board, HRB EIA-2017-019）、欧盟神经退行性疾病研究联合计划（EU Joint Programme – Neurodegenerative Disease Research, JPND）、安德鲁·莱登奖学金、爱尔兰临床神经科学研究所（Irish Institute of Clinical Neuroscience, IICN）以及艾里斯·奥布莱恩基金会资助。详细方法学细节可参见以下文献：《肌萎缩侧索硬化与原发性侧索硬化的杏仁核病理学》。作者：Chipika RH、Christidi F、Finegan E、Li Hi Shing S、McKenna MC、Chang KM、Karavasilis E、Doherty MA、Hengeveld JC、Vajda A、Pender N、Hutchinson S、Donaghy C、McLaughlin RL、Hardiman O、Bede P。发表于《神经科学杂志》（J Neurol Sci），2020年7月18日在线预印版，文章编号：117039。DOI：10.1016/j.jns.2020.117039，PMID：32713609。