Erratum: Tear Film Osmolarity in Patients with Diabetes Mellitus

Purpose: To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. Methods: In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in milliosmole (mOsm) was measured by using an auto-osmometer. The serum levels of glycosylated hemoglobin (HbA1c) and blood glucose in all participants were also measured. Mean outcome measures were TFO and its relationship with HbA1c level and duration of DM. Results: Mean TFO was 320.40 ± 21.80 mOsm/l in the study group and 308.22 ± 18.16 mOsm/l in the control group (p < 0.001). The TFO values were significantly associated with duration of DM (r = 0.476, p < 0.001), but no significant correlation was found with HbA1c level (r = 0.225, p = 0.114). Conclusions: The study shows a significantly higher TFO in patients with DM than in the healthy controls. TFO also correlates with the duration of DM.

研究目的：比较糖尿病（Diabetes Mellitus, DM）患者与健康正常人的泪膜渗透压（Tear Film Osmolarity, TFO）水平。
方法：本研究为前瞻性病例对照研究，共纳入46名正常受试者作为对照组，55名糖尿病患者作为试验组，对两组的泪膜渗透压（TFO）进行检测。采用自动渗透压仪测量以毫渗透压摩尔（milliosmole, mOsm）为单位的TFO值；同时检测所有受试者的糖化血红蛋白（Glycosylated Hemoglobin, HbA1c）血清水平与血糖水平。本研究的主要结局指标为TFO水平，以及TFO与糖化血红蛋白水平、糖尿病病程的相关性。
结果：试验组患者的平均泪膜渗透压为320.40±21.80 mOsm/L，对照组为308.22±18.16 mOsm/L，组间差异具有统计学意义（p < 0.001）。泪膜渗透压水平与糖尿病病程呈显著正相关（r=0.476，p < 0.001），但与糖化血红蛋白水平无显著相关性（r=0.225，p=0.114）。
结论：本研究表明，糖尿病患者的泪膜渗透压水平显著高于健康对照组人群，且泪膜渗透压水平与糖尿病病程存在相关性。