Dataset for a Multivariate Genome-Wide Association Study of Psycho-Cardiometabolic Multimorbidity

This dataset contains summary statistics from a multivariate genome-wide association study of major depression, coronary artery disease, and type 2 diabetes (i.e., psycho-cardiometabolic multimorbidity).

There are two sets of summary statistics: version with UK Biobank (effective sample size = 562,507) and version without UK Biobank (effective sample size = 156,717). Summary statistics for non-heterogeneous variants are also provided (obtained by removing variants with Q SNP P < 5e-8 and directionally discordant univariate effect estimates).

For a given single nucleotide polymorphism (SNP), the summary statistics include the chromosome; position; minor allele frequency; effect allele; non-effect allele; effect of the SNP on the common factor; standard error; ratio of effect/SE; p-value of Z_Estimate; chi-square statistic, providing the heterogeneity estimate for that SNP (equivalent to the Q SNP index); chi-square degrees of freedom; chi-square p-value; whether effect estimates from three input genome-wide association studies were directionally concordant.

本数据集收录了关于重度抑郁症、冠状动脉疾病和2型糖尿病（即心理-心血管-代谢多病共存）的多变量全基因组关联研究的汇总统计数据。数据集分为两组汇总统计数据：包含英国生物样本库（有效样本量=562,507）的版本和不包含英国生物样本库（有效样本量=156,717）的版本。同时，还提供了非同质变异的汇总统计数据（通过移除Q SNP P值小于5e-8的变异以及方向不一致的单变量效应估计值获得）。对于特定的单核苷酸多态性（SNP），汇总统计数据包括染色体；位置；等位基因频率；效应等位基因；非效应等位基因；SNP对常见因素的效应；标准误；效应/SE比率；Z估计值的p值；卡方统计量，提供该SNP的异质性估计（相当于Q SNP指标）；卡方自由度；卡方p值；以及来自三个输入全基因组关联研究的效果估计值是否方向一致。