Convergent Total Synthesis of Principinol D, a Rearranged Kaurane Diterpenoid
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https://figshare.com/articles/dataset/Convergent_Total_Synthesis_of_Principinol_D_a_Rearranged_Kaurane_Diterpenoid/8089055
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资源简介：
The
total synthesis of principinol D, a rearranged kaurane diterpenoid,
is reported. This grayanane natural product is constructed via a convergent
fragment coupling approach, wherein the central seven-membered ring
is synthesized at a late stage. The bicyclo[3.2.1]octane fragment
is accessed by a Ni-catalyzed α-vinylation reaction. Strategic
reductions include a diastereoselective SmI2-mediated ketone
reduction with PhSH and a new protocol for selective ester reduction
in the presence of ketones. The convergent strategy reported herein
may be an entry point to the larger class of kaurane diterpenoids.
创建时间：
2019-05-02
