Single Cell Transcriptomic Profiling of MYBPC3-associated Hypertrophic Cardiomyopathy Across Species Reveals Conservation of Biological Process but Not Gene Expression

Single RNA sequencing analysis of myosin binding protein C3 (mybpc-3) associated Hypertrophic Cardiomyopathy to identify single cell gene expression changes across common pathological mechanisms and species-specific distinctions in human, feline, and murine heart tissues. Interventricular septal (IVS) myectomy heart tissue was obtained from human patients and felines with left ventricular outflow tract obstruction (LVOT) and organ donors or control [as in the case for felines]. Whole heart from a knock-in mouse model with a truncated form of myosin binding protein C3 and Wild Type were sampled using snRNA-seq.