AMIGO2 overexpression effect on colon cancer cell line

Analysis of SW480 colon cancer cells overexpressing AMIGO2. Result provide insight into the role of AMIGO2 in colon cancer. Amphoterin-inducible genes and open reading frame 2 (AMIGO2) have been reported to play a role in promoting malignant transformation in several cancer types, including human colon cancer. However, the exact role of AMIGO2 in human colorectal cancer invasiveness remains unclear. We established an AMIGO2 overexpression line (SW480_A9) and a vector control line (SW480_E11) using a human colon cancer cell line (SW480) and analyzed differential expression of AMIGO2 on a microarray (Toray 3D-Gene). Microarray analysis was performed on two groups of SW480 cells, i.e., AMIGO2-overexpression (SW480_A9) and vector control (SW480_E11).