Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation

Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation Descriptor: CHLORIDE ION, Casein kinase I isoform delta, N-(2,2-difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-2-{[2-(trifluoromethoxy)benzoyl]amino}-1,3-thiazole-4-carboxamide, ... Authors: Richter, J, Bischof, J, Zaja, M, Kohlhof, H, Othersen, O, Vitt, D, Alscher, V, Pospiech, I, Garcia-Reyes, B, Berg, S, Leban, J, Knippschild, U. Deposit date: 2014-06-30 Release date: 2014-07-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Difluoro-dioxolo-benzoimidazol-benzamides As Potent Inhibitors of CK1 delta and epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation. J.Med.Chem., 57, 2014

二氟二氧杂环苯并咪唑苯甲酰胺类化合物作为CK1δ（Casein kinase 1 delta）与CK1ε的强效抑制剂，对癌细胞增殖具有纳摩尔级抑制活性
描述符: 氯离子（CHLORIDE ION）、酪蛋白激酶1亚型δ（Casein kinase I isoform delta）、N-(2,2-二氟-5H-[1,3]二氧杂环戊并[4,5-f]苯并咪唑-6-基)-2-{[2-(三氟甲氧基)苯甲酰基]氨基}-1,3-噻唑-4-甲酰胺，……
作者: Richter, J、Bischof, J、Zaja, M、Kohlhof, H、Othersen, O、Vitt, D、Alscher, V、Pospiech, I、Garcia-Reyes, B、Berg, S、Leban, J、Knippschild, U
存入日期: 2014-06-30
发布日期: 2014-07-30
最后修改日期: 2024-05-08
实验方法: X射线衍射（2.4埃）
引用文献: 二氟二氧杂环苯并咪唑苯甲酰胺类化合物作为CK1δ与CK1ε的强效抑制剂，对癌细胞增殖具有纳摩尔级抑制活性。《药物化学杂志（J.Med.Chem.）》，第57卷，2014年