DATASET ON ASSESSMENT OF INTERACTION OF SELECTED ANTIMALARIA ACTs DRUGS WITH ANTIBIOTICS AND AQUEOUS SEED EXTRACTS OF Garcinia cola AND Cola nitida IN Plasmodium berghei INFECTED ALBINO RATS

This dataset is from a study that determined the changes in parasitaemia, chemo-suppression and selected biochemical parameters in Plasmodium berghei passaged albino rats orally co-administered artemether lumefantrine, artesunate amodiaquine and dihydroartemisin piperaquine phosphate with rifampicin, erythromycin and aqueous seed extracts of Cola nitida and Garcinia kola.

Using Rane’s test 27 albino rats randomized into 9 groups of 3 rats each were passaged with Plasmodium berghei except for the control Group A administered water only. Some infected groups were treated with water, the ACTs and aqueous seed extracts of Cola nitida and Garcinia kola alone while other infected rats were treated with the ACTs co-administered with aqueous seed extracts, rifampicin and erythromycin respectively (see Experimental design). All treatments with aqueous seed extracts and rifampicin commenced 14 days before inoculation with Plasmodium berghei and continued with other treatments on day 3 post inoculation through day 6 using steel cannula. Serum ALT and AST activities, serum bilirubin, urea, creatinine, sodium, potassium, bicarbonate, chloride, total protein, albumin and globulin concentration as well as full blood count were determined from blood collected through ocular puncture using standard methods on day 9.

本数据集源自一项研究，该研究旨在探究经伯氏疟原虫（Plasmodium berghei）传代的白化大鼠，在经口联合给予蒿甲醚-苯芴醇（artemether lumefantrine）、青蒿琥酯-阿莫地喹（artesunate amodiaquine）、磷酸双氢青蒿素-哌喹（dihydroartemisin piperaquine phosphate），分别与利福平（rifampicin）、红霉素（erythromycin）以及亮叶可乐（Cola nitida）、非洲山竹子（Garcinia kola）的种子水提物时，其虫血症、化学抑制效应及选定生化指标的变化情况。

采用Rane试验（Rane’s test）方法，将27只白化大鼠随机分为9组，每组3只。除仅给予蒸馏水的对照组A外，其余各组大鼠均经伯氏疟原虫传代感染。部分感染组分别单独给予蒸馏水、青蒿素联合疗法（ACTs, Artemisinin-based Combination Therapies）以及亮叶可乐与非洲山竹子的种子水提物；其余感染大鼠则分别联合给予青蒿素联合疗法与种子水提物、利福平、红霉素（详见实验设计）。所有种子水提物与利福平的给药均于伯氏疟原虫接种前14天启动，并于接种后第3天至第6天通过钢套管续予其余治疗药物。于第9天通过眼球穿刺采集血液，采用标准方法检测血清谷丙转氨酶（ALT）、谷草转氨酶（AST）活性，血清胆红素、尿素、肌酐、钠、钾、碳酸氢根、氯离子浓度，总蛋白、白蛋白、球蛋白含量以及全血细胞计数。