Electron transport chain: OXPHOS system in mitochondria

An electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set of mediating biochemical reactions. These H+ ions are used to produce adenosine triphosphate (ATP), the main energy intermediate in living organisms, as they move back across the membrane. In mitochondria, it is the conversion of oxygen to water, NADH to NAD+ and succinate to fumarate that drives the transfer of H+ ions. Source: Wikipedia ([[wikipedia:Electron_transport_chain]]) Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP111 CPTAC Assay Portal]

电子传递链（ETC）通过一系列介导的生化反应，将电子供体（如NADH）与电子受体（如O2）之间的化学反应与质子（H+）离子穿过膜的转移耦合起来。这些H+离子在质子通过膜返回时被利用以产生三磷酸腺苷（ATP），这是生物体中主要的能量中介体。在细胞线粒体中，氧转化为水、NADH转化为NAD+以及琥珀酸转化为富马酸的过程驱动了H+离子的转移。资料来源：维基百科（[wikipedia:Electron_transport_chain]）。该途径上的蛋白质具有针对其的靶向检测方法，可通过[https://assays.cancer.gov/available_assays?wp_id=WP111 CPTAC检测门户]获取。