Dataset of fraction unbound values in the in vitro incubations

Database containing information on fraction unbound in human or animal plasma, hepatocytes, microsomes and recombinant cytochromes. Data on a free fraction in plasma and different in vitro models are supplemented with the following information: the experimental method used for the assessment of the degree of drug binding, protein or cell concentration in the incubation, and other experimental conditions, if different from the standard ones, species, reference to the source publication, and the author's name and date of publication.

本数据库收录了人类或动物血浆、肝细胞、微粒体（microsomes）以及重组细胞色素（recombinant cytochromes）中的药物游离分数（fraction unbound）相关信息。针对血浆及各类体外模型（in vitro models）中的游离分数数据，本数据库补充了以下配套信息：用于评估药物结合程度的实验方法、孵育体系中的蛋白质或细胞浓度、与标准实验条件存在差异的其他实验条件、受试物种、原始文献引用信息，以及作者姓名与发表日期。