NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA
收藏reactome.org2025-03-25 收录
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NPM2 dissociates phosphorylated PRM1 from DNA (inferred from mouse homologs). Deletion of Npm2 from mouse oocytes does not prevent protamine removal (Burns et al. 2003), indicating that other factors such as Npm1 and Npm3 may act redundantly with Npm2 (Okuwaki et al. 2012).
NPM2能够将磷酸化的PRM1从DNA中解离(据小鼠同源物推断)。小鼠卵母细胞中Npm2的缺失并未阻止组蛋白去除(Burns等人,2003年),这表明其他因素,如Npm1和Npm3,可能与Npm2发挥冗余作用(Okuwaki等人,2012年)。
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