Melanopsin-mediated amplification of cone signals in the human visual cortex

The ambient daylight variation is coded by melanopsin photoreceptors and their luxotonic activity increases towards midday when colour temperatures are cooler, and irradiances are higher. Although melanopsin and cone photoresponses can be mediated via separate pathways, the connectivity of melanopsin cells across all levels of the retina enables them to modify cone signals. The downstream effects of melanopsin-cone interactions on human vision are however, incompletely understood. Here, we determined how the change in daytime melanopsin activation affects the human cone pathway signals in the visual cortex. A 5-primary silent-substitution method was developed to evaluate the dependence of cone-mediated signals on melanopsin activation by spectrally tuning the lights and stabilising the rhodopsin activation under a constant cone photometric luminance. The retinal (white noise electroretinogram, wnERG) and cortical responses (visual evoked potential, wnVEP) were simultaneously recorded wi..., , , # Melanopsin-mediated amplification of cone signals in the human visual cortex

[https://doi.org/10.5061/dryad.12jm63z62](https://doi.org/10.5061/dryad.12jm63z62)

The data are electrophysiological recordings of the human electroretinogram (ERG) and visual evoked potential (VEP) measured under conditions of 5-primary silent substitution.

## Description of the data and file structure

Sheet 1: Overview 

Sheet 2: Fig. 2 Data:

Column C to G: Irradiance output (Watts.cm-2) of the 5-primary lights (B, C, G, A, R) as a function of wavelength (nm) in the low melanopsin adaptation background (ilow).

Column I to M: Irradiance output (Watts.cm-2) of the 5-primary lights as a function of wavelength (nm) in the high melanopsin adaptation background (ihigh).

Column P to S: Cone-directed wnERG and wnVEP responses (µV) as a function of time (ms) measured under low (ilow) or high (ihigh) melanopsin excitation.

Sheet 3: Fig. 3 Data:

Mean and SEM of the cone-directed wnERG and wnVEP amplitudes (µV...