Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink
收藏Protein Data Bank Japan2023-10-11 更新2026-03-21 收录
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Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Cisplatin, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), ... Authors: Ouzon-Shubeita, H, Vilas, C.K, Lee, S. Deposit date: 2019-08-20 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of the Mutagenic Bypass of the Major Cisplatin-DNA Lesion by Human DNA Polymerase Beta Reveal Insights into Cisplatin-Induced Mutagenesis To Be Published
人类DNA聚合酶β(DNA polymerase beta)将dAMPNPP错掺入顺铂(Cisplatin)Pt-GG链内交联的5'G位点的三维结构
描述项:2'-脱氧-5'-O-[(R)-羟基{[(R)-羟基(膦酰氧基)磷酰基]氨基}磷酰基]腺苷、顺铂、DNA(5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3')……
作者:Ouzon-Shubeita H、Vilas C.K、Lee S
提交日期:2019年8月20日
发布日期:2020年8月26日
最后修改日期:2023年10月11日
实验方法:X射线衍射(X-RAY DIFFRACTION,分辨率2.3埃(Å))
引用文献:《人类DNA聚合酶β介导的主要顺铂-DNA损伤诱变旁路结构:揭示顺铂诱导诱变的机制》(待发表)
创建时间:
2019-08-20



