EFFECT OF EXERCISE TRAINING ON ENDOTHELIAL FUNCTION IN INDIVIDUALS WITH EXCESS WEIGHT: A SYSTEMATIC REVIEW WITH META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS

Individuals with excess weight have impaired endothelial function and increased risk of atherosclerosis. Exercise training is essential for the management of excess weight, but little is known about its effects on endothelial function in this population. The objective of this systematic review was to examine the effects of exercise training on endothelial function in individuals with excess weight. Methods: Our review study included only randomized controlled trials (RCTs) involving adults (≥18 years of age) with body mass index (BMI) ≥25.0 kg/m2. Our search was conducted in the electronic bases MEDLINE (PubMed), Cochrane, LILACS and EMBASE and in the gray literature. We performed random-effects analyses for effect estimates and used 95% prediction intervals (95% PI) for estimating the uncertainty of the study results. We also assessed the risk of bias using RoB 2 tool and the strength of the body of evidence (GRADE) of the studies. RStudio software was used for statistical analyses.

超重个体存在内皮功能（endothelial function）受损，且动脉粥样硬化（atherosclerosis）风险升高。运动训练（exercise training）是超重管理的必要手段，但目前对该人群中运动训练对内皮功能的影响尚不清楚。本系统评价的目的是探讨运动训练对超重个体内皮功能的影响。
方法：本综述仅纳入体质量指数（body mass index, BMI）≥25.0 kg/m²的成年（≥18岁）受试者的随机对照试验（randomized controlled trials, RCTs）。检索范围涵盖MEDLINE（PubMed）、Cochrane、LILACS、EMBASE等电子数据库以及灰色文献（gray literature）。我们采用随机效应模型进行效应量估计，并借助95%预测区间（95% prediction intervals, 95% PI）评估研究结果的不确定性。同时采用RoB 2工具评估偏倚风险，并通过GRADE标准评估研究证据体的强度。本研究采用RStudio软件完成统计学分析。