FCGR3A-mediated phagocytosis

The Fc gamma receptors (FCGRs) have been reported to facilitate Leishmania internalization, especially when in its amastigote form (Ueno et al. 2012). Following cell-to-cell propagation within an established infection or reinfection of a previously infected host, the IgG produced by the host covers the surface of Leishmania amastigote parasites, making them more susceptible to phagocytosis through FCGRs (Polando et al. 2013).<br><br>Classically, phagocytosis via FCGRs has been associated with the subsequent activation of Rac GTPases and Cdc42 which in turn activate the phagocyte's NADPH oxidase, contributing to the activation of killing mechanisms (Ueno et al. 2012).

Fcγ受体（FCGRs）已被报道能够促进利什曼原虫的内化，尤其是当其处于无性繁殖形式（阿玛斯塔吉体）时（Ueno等，2012年）。在建立感染或先前感染宿主的再感染过程中，宿主产生的IgG抗体覆盖了利什曼原虫阿玛斯塔吉体寄生虫的表面，使其更易受到通过FCGRs介导的吞噬作用（Polando等，2013年）。传统上，通过FCGRs介导的吞噬作用与Rac GTPases和Cdc42的后续激活相关联，而这两者进而激活吞噬细胞的NADPH氧化酶，从而有助于杀伤机制的激活（Ueno等，2012年）。