BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (ATAC III). BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (ATAC III)

We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells. Overall design: ATAC-seq analysis of 9 samples: Activated WT CD8 T cells (n=3), Activated Arid1a KO CD8 T cells (n=3), Activated WT CD8 T cells treated with Arid1a inhibitor (n=3).