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Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs (GCN-TM1i conformation)

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Protein Data Bank Japan2024-10-30 更新2026-05-23 收录
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Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs (GCN-TM1i conformation) Descriptor: C-terminal deletion mutant of gap junction alpha-1 protein (Cx43-M257) Authors: Lee, H.J, Cha, H.J, Jeong, H, Lee, S.N, Lee, C.W, Woo, J.S. Deposit date: 2022-05-07 Release date: 2023-01-25 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM. Nat Commun, 14, 2023

POPE纳米圆盘(POPE nanodiscs)中聚焦半通道的C端截短型连接蛋白43(connexin43, Cx43/GJA1)间隙连接细胞间通道结构(GCN-TM1i构象) 描述项:间隙连接α-1蛋白(gap junction alpha-1 protein, GJA1)的C端缺失突变体(Cx43-M257) 作者:Lee, H.J、Cha, H.J、Jeong, H、Lee, S.N、Lee, C.W、Woo, J.S. 存档日期:2022-05-07 发布日期:2023-01-25 最后修改日期:2024-10-30 实验方法:电子显微镜(分辨率3.8 Å) 引用文献:《利用冷冻电镜(cryo-EM)解析人类Cx43/GJA1间隙连接通道的构象变化》,《自然通讯》(Nat Commun),第14卷,2023年

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2022-05-07
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