Assessing RIPK3 dependent genes in death-resistant and death-susceptible MEFs encoding activatable RIPK3-system
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP543111
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资源简介：
The full transcriptional RIPK3-dependent transcriptional potential in MEFs is unknown. Here, we found that RIPK3 is a dominant driver of anti-viral and inflammatory transcription in MEFs. Overall design: Ripk3-2xFV immortalized mouse embryonic fibroblasts (MEFs) lacking MLKL, were treated with BB homodimerizer or BB homodimerizer and qVD (pan-caspase inhibitor) for 4 or 24hrs (n=3-6/group). MEF RNA lysates were then submitted for bulk RNA sequencing. NOTES: AP1 = BB, qVD= pan caspase inhibitor, RXMM = ripk3-2xFVfl/fl:ubcERT2cre+MLKL-/-
创建时间：
2025-05-08
