Conservation of genes upregulated in response to clean epidermal wounding.

Twenty-seven genes that are transcriptionally upregulated after epidermal wounding in Drosophila and mammals. “Fly gene symbol” corresponds to Flybase gene symbol notation. Fly gene symbols listed are statistically significant (FDR<0.01) after puncture or trypsin puncture wounding for at least one timepoint (30, 60, or 120 minutes). The mammalian ortholog or the closest related mammalian protein to the listed fly gene is listed in the “Mammalian gene symbol” column. The listed mammalian genes were determined to be significantly upregulated after various wounding treatments. The “References” column lists the publications that identified the respective mammalian gene wound upregulation. “Trypsin puncture up” or “Puncture up” columns indicate if the corresponding fly gene was significantly upregulated (Y) or was not significantly upregulated (N) for at least one timepoint in the Drosophila microarrays.