Reciprocal Regulation between the Circadian Clock and Hypoxic Signaling in Mammals. Reciprocal Regulation between the Circadian Clock and Hypoxic Signaling in Mammals

We propose that the clock plays an important role in fine-tuning the hypoxic response under pathophysiological conditions, which can serve as a strategy to reduce the severity of fatal hypoxia-related diseases. Overall design: RNA-seq between wildtype and mutant MEF cells and Chip-seq in U2OS cells