Transcriptome profiling of patients with critical illness myopathy

Critically ill, immobilized and mechanically ventilated intensive care unit (ICU) patients develop severe muscle wasting and impaired muscle function. This condition is referred to as critical illness myopathy (CIM). This study aimed to obtain the gene signature of CIM. Percutaneous conchotome muscle biopsies from the tibialis anterior muscle was used for RNA sequencing from seven mechanically ventilated ICU patients and six control subjects.