TMBIM-correlated genes from glioma datasets

This dataset contains foiur Excel workbooks composed of multiple sheets corresponding to members of the Transmembrane BAX Inhibitor Motif-containing (TMBIM) gene family (TMBIM1–TMBIM6) across different glioma transcriptomic datasets, including TCGA-GBMLGG, TCGA-GBM, TCGA-LGG, and Rembrandt cohorts. For each TMBIM gene, the workbook reports lists of the most strongly correlated genes based on Pearson correlation analysis of normalized gene expression data. The number of top correlated genes included varies according to the dataset: TCGA-GBMLGG: top 300 correlated genes; TCGA-GBM: top 100 correlated genes; TCGA-LGG: top 100 correlated genes; REMBRANDT: top 300 correlated genes. Each sheet contains: correlated genes identified using HGNC gene symbols; Pearson correlation coefficients (r) between the selected genes and all TMBIM family members (TMBIM1–TMBIM6); rankings ordered according to decreasing correlation strength. Gene–gene correlations were computed across all samples within each cohort using normalized transcriptomic expression data. The dataset enables comparative analysis of TMBIM-associated transcriptional networks across independent glioma datasets and between glioblastoma multiforme (GBM) and lower-grade glioma (LGG) cohorts. In addition, a separate Excel workbook contains pairwise intersection analyses of TMBIM-correlated gene sets. For each TMBIM pair, shared genes were defined as the intersection of genes present in the respective top-ranked correlation lists of each gene. This file enables direct comparison of overlapping transcriptional programs between TMBIM family members. All supplementary tables belongs to the study Transcriptomic Evidence Identifies Two TMBIM Subgroups with Opposing Prognostic Associations in Glioma, published in Biology.