Cryo-EM structure of epinephrine-bound alpha-2A-adrenergic receptor in complex with heterotrimeric Gi-protein

Cryo-EM structure of epinephrine-bound alpha-2A-adrenergic receptor in complex with heterotrimeric Gi-protein Descriptor: Endolysin,Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Lou, J.S, Su, M, Wang, J, Do, H.N, Miao, Y, Huang, X.Y. Deposit date: 2024-06-19 Release date: 2024-09-11 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Distinct binding conformations of epinephrine with alpha- and beta-adrenergic receptors. Exp.Mol.Med., 56, 2024与异三聚体Gi蛋白（heterotrimeric Gi-protein）结合的肾上腺素结合态α₂A肾上腺素能受体（alpha-2A-adrenergic receptor）的冷冻电镜（Cryo-EM）结构 描述项：内溶素（Endolysin）、α₂A肾上腺素能受体（alpha-2A adrenergic receptor）、鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2（Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2）、鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(T)亚基β-1（Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1）…… 作者：Lou J.S.、Su M.、Wang J.、Do H.N.、Miao Y.、Huang X.Y. 提交日期：2024-06-19 发布日期：2024-09-11 最后修改日期：2024-10-16 实验方法：电子显微镜（分辨率2.8埃） 引用文献：肾上腺素与α、β肾上腺素能受体的差异化结合构象，《Exp. Mol. Med.》（《实验与分子医学》），56卷，2024年