Genome-wide analysis of gene expression by SCTR siRNA transfection in breast cell line MCF-10A. Homo sapiens

Analysis of tumor suppression by cell cycle-related genes which are regulated by SCTR(Secretin receptor) at gene expression level. The hypothesis tested in the present study was that SCTR regulates cell cycle-related genes toward tumor suppression in normal breast cells. Results suggest that normal breast cells have tumor suppressor activity when SCTR was knocked down by siRNA. Overall design: Total RNA obtained from MCF-10A where SCTR was knocked down by siRNA