Transcriptional profile of stemness in the ovarian surface epithelium. Transcriptional profile of stemness in the ovarian surface epithelium

We leverage RNA sequencing to identify the transcriptional changes assocaited with several experimental conditions that induce a stemness phenotype in the ovarian surface epithelium, including spheroid culture, Snail overexpression, and BRCA1 deletion Overall design: RNA sequencing of mOSE cultured as monolayers or spheroids (+/- TGFB1), and monolayer cells overexpressing Snail, or following deletion of BRCA1 (n=3 for each experiment)