Catalytic activity of short peptides on the loading of soluble HLA-DR1 with HA306-318

*‘Minimal peptide-MLE’ and ‘catalytic tripeptides’ are introduced in this study, catalytic activity for ‘invariant chain derived peptides’ has been reported for LRMK and LRMKLPK [16] and for LRKPPKPV [17].
**The ‘Catalytic Rate Enhancement’ coefficient (k) represents the relative increase of the spontaneous loading rate (rspont) in the presence of the catalytic peptide (Pcat). The total rate (rtot) can be calculated by (rtot = rspont+k [Pcat] rspont).
***“rel. cat. Activity” indicates the relative catalytic activity of peptide derivatives and is expressed as percentage in reference to the catalytic rate enhancement of Ac-FR-NH2.