Molecular mechanism of EPC1-PHF1 fusion protein (Microarray Homo Sapiens). Molecular mechanism of EPC1-PHF1 fusion protein (Microarray Homo Sapiens)
收藏NIAID Data Ecosystem2026-03-12 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA682182
下载链接
链接失效反馈官方服务：
资源简介：
In this study, we characterize the fusion protein produced by the EPC1-PHF1 translocation in Low Grade Endometrial Stromal Sarcoma (LG-ESS) and Ossifying FibroMyxoid Tumors (OFMT). We express the fusion protein and necessary controls in K562 Cells. The fusion protein assembles a mega-complex harboring both NuA4/TIP60 and PRC2 subunits and enzymatic activities and leads to mislocalization of chromatin marks in the genome, linked to aberrant gene expression. Overall design: We profiled the gene expression in K562 cells expressing tagged EPC1-PHF1 fusion protein or EPC1(1-581) or PHF1 or tag only. Total RNA was analyzed on Illumina Human HT-12 V4.0 expression beadchip by McGill University and Genome Québec innovation Centre
创建时间：
2020-12-02
