Structure of human protein kinase CK2 catalytic subunit (CK2alpha', CSNK2A2 gene product) in complex with the cyclic peptidomimetic compound 12 discovered by high-throughput screening

Structure of human protein kinase CK2 catalytic subunit (CK2alpha', CSNK2A2 gene product) in complex with the cyclic peptidomimetic compound 12 discovered by high-throughput screening Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Casein kinase II subunit alpha', ... Authors: Niefind, K, Werner, C, Pietsch, M, Eimermacher, S, Lindenblatt, D. Deposit date: 2024-05-14 Release date: 2025-06-11 Last modified: 2026-07-01 Method: X-RAY DIFFRACTION (1.161 Å) Cite: Discovery and characterization of a novel class of cyclic peptidic compounds inhibiting the subunit interaction of the protein kinase CK2 alpha 2 beta 2 holoenzyme Rsc Chem Biol, 2026本数据集为人源蛋白激酶CK2催化亚基CK2α'（CK2alpha'，CSNK2A2基因编码产物）与经高通量筛选发现的环状拟肽化合物12形成的复合物的结构。 配体描述：1,2-乙二醇、氯离子、酪蛋白激酶II亚基α'…… 作者：Niefind, K、Werner, C、Pietsch, M、Eimermacher, S、Lindenblatt, D 存入日期：2024-05-14 发布日期：2025-06-11 最后更新日期：2025-11-05 实验方法：X射线衍射（分辨率1.161 Å） 引用文献：《一类新型环状肽类化合物的发现与表征：可抑制蛋白激酶CK2α2/β2全酶的组装》（待发表）