Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies

A set of metal carbonyl
cluster-boronic acid conjugates of the
group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative
effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231)
and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity
followed the order Ru > Os > Fe for the MDA-MB-231 cells, although
the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A
cells. The osmium species {Os3(CO)10(μ-H)­[μ-SC6H4-p-B­(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)­(μ-SC6H4-p-OH)] (2-OH), which showed comparable
cytotoxicity. Mode of action studies pointed to an apoptotic pathway
for cell death.