Expression data from WT (Pparafl/fl) mice and hepatocyte-specific PPARα disruption (Ppara△Hep) mice liver tissue at 12 hours after PHx or Sham operation

PPARα act as the master of lipid metabolism in liver, however, the changes of its target genes after PHx and the effects of PPARα on regenerative genes were unknown. At 12 to 24 hours after PHx, the mice develope marked steatosis, therefore the time point of 12 hour after PHx was choosen to perform microarray analysis. We used microarray to detail the gene expression of WT (Pparafl/fl) mice and hepatocyte-specific PPARα disruption (Ppara△Hep) mice liver tissue at 12 hour after PHx or Sham operation The time points of 12 hour after PHx or Sham operation were choosed for RNA extraction and hybridization on Affymetrix microarrays. The mice were devided into four groups: 1. Pparafl/fl mice at 12 hours after Sham operation, 2.Pparafl/fl mice at 12 hours after PHx operation, 3. Ppara△Hep mice at 12 hours after Sham operation, 3. Ppara△Hep mice at 12 hours after PHx operation.