UCH proteinases

DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997).

乌布C端水解酶（UCH）家族的DUBs（去泛素化酶）为硫醇蛋白酶，其结构通常以N端催化域开始，有时随后接有C端延伸结构，这些延伸结构介导蛋白质之间的相互作用。人类拥有四种UCH DUBs（UCH-L1、UCH-L3、UCH37/UCH-L5和BAP1），它们可分为较小的UCH DUBs（UCH-L1和UCH-L3），后者可从泛素C端切割出小的离去基团（Larsen等人，1998年），以及较大的UCH DUBs（UCH37和BAP1），后者能够解聚多泛素链（Misaghi等人，2009年，Lam等人，1997年）。