MicroRNA profiling of plasma exosomes of ESCC patients

MiRNA arrays were performed for the plasma exosomes of ESCC patients before treatment. The tumor regression grade of the primary tumor (TRG-PT) was used to evaluate the therapeutic effect of chemoradiotherapy (CRT). Patients classified as Grade 3 were considered sensitive to CRT (n=4), while those classified as Grade 0 or 1a were considered resistant to CRT (n=4). miRCURY LNA microRNA arrays were performed in a cohort of eight cases to investigate the difference in the miRNA expression between CRT-sensitive and CRT-resistant patients.