Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy

Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy Descriptor: 3-CHLORO-6-FLUORO-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, octyl beta-D-glucopyranoside Authors: Marquette, J.-P, Mathieu, M. Deposit date: 2010-11-19 Release date: 2011-02-23 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.14 Å) Cite: Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy Chemmedchem, 6, 2011

具有异常结合模式的新型磺酰噻二唑类化合物：兼具高效力与体内活性的部分型双过氧化物酶体增殖物激活受体γ/δ（Peroxisome Proliferator-Activated Receptor, PPAR）激动剂
描述物：3-氯-6-氟-N-[2-[4-[(5-异丙基-1,3,4-噻二唑-2-基)氨磺酰基]苯基]乙基]-1-苯并噻吩-2-甲酰胺、过氧化物酶体增殖物激活受体δ、辛基β-D-吡喃葡萄糖苷（octyl beta-D-glucopyranoside）
作者：Marquette, J.-P、Mathieu, M.
提交日期：2010-11-19
发布日期：2011-02-23
最后修改日期：2024-05-01
实验方法：X射线衍射（3.14埃）
引用：《具有异常结合模式的磺酰噻二唑类化合物：兼具高效力与体内活性的部分型双过氧化物酶体增殖物激活受体γ/δ激动剂》，Chemmedchem，第6卷，2011年