ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas.
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https://www.ncbi.nlm.nih.gov/sra/SRP450256
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RNA-sequencing of cancer cell lines derived from genetically engineered mouse models KPC (Ptf1a-Cre; LSL-KrasG12D; p53f/+) vs KPCAf/f (Ptf1a-Cre; LSL-KrasG12D; p53f/+; Arid1af/f) followed by GSEA revealed that gene signatures for EMT and stem cells were enriched in KPCAf/f, consistent with phenotypic observations of increased migration, invasion and anchorage-independent growth. Overall design: Comparative gene expression profiling analysis of RNA-seq data for KPC vs KPCAf/f cancer cell lines
创建时间:
2023-07-20



