Structural characterization of Silver complexes based on ester derivatives of bis(pyrazol-1-yl)acetate ligands

This projects aims to elucidate the local structure on a series of Silver and Copper complexes based on ester derivatives of bis(pyrazol-1-yl)acetate ligands and stabilized with tri-n-butylphosphine or 1,3,5-triaza-7-phosphaadamantane ligands. These complexes are promising candidates in the field of biomedicine and specifically in cancer treatment. Previous data acquired on different cancerous cell lines proved the effectiveness of the treatment, inducing paraptotic cell death and showing higher citotoxicity that the reference metallodrug cisplatin. In this context our group aims to study the local coordination in these Silver complexes in view of a future application as both standalone drugs and/or in pairing with a drug delivery vector such as gold nanoparticles and nanorods.