Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor

Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor Descriptor: 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERAZIN-1-YL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE, Mitogen-activated protein kinase 14, SULFATE ION Authors: Stelmach, J.E, Liu, L, Patel, S.B, Pivnichny, J.V, Scapin, G, Singh, S, Hop, C.E.C.A, Wang, Z, Cameron, P.M, Nichols, E.A, O'Keefe, S.J, O'Neill, E.A, Schmatz, D.M, Schwartz, C.D, Thompson, C.M, Zaller, D.M, Doherty, J.B. Deposit date: 2002-07-22 Release date: 2002-12-11 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 13, 2003

与二氢喹唑啉酮类抑制剂结合的p38丝裂原活化蛋白激酶（p38 MAP kinase）晶体结构
描述：1-(2,6-二氯苯基)-5-(2,4-二氟苯基)-7-哌嗪-1-基-3,4-二氢喹唑啉-2(1H)-酮、丝裂原活化蛋白激酶14（Mitogen-activated protein kinase 14）、硫酸根离子
作者：Stelmach, J.E、Liu, L、Patel, S.B、Pivnichny, J.V、Scapin, G、Singh, S、Hop, C.E.C.A、Wang, Z、Cameron, P.M、Nichols, E.A、O'Keefe, S.J、O'Neill, E.A、Schmatz, D.M、Schwartz, C.D、Thompson, C.M、Zaller, D.M、Doherty, J.B
提交日期：2002-07-22
发布日期：2002-12-11
最后修改日期：2024-02-14
测试方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.4埃（Å）
引用文献：《强效口服生物可利用的p38丝裂原活化蛋白激酶二氢喹唑啉酮类抑制剂的设计与合成》，发表于《Bioorg.Med.Chem.Lett.》，第13卷，2003年