Effects of antibiotics aerosolization on the growth of experimental B16 lung metastases and on the activation of lung immune effector cells.

the purpose of the experiment was to evaluate the effects of antibiotic treatment on the implantation of tumor cells in the lungs in mice pre-treated with aerosolized antibiotics or saline.
Conclusion:
At the end of the treatment, the number of macroscopic melanotic metastases was significantly reduced in antibiotic- versus saline-treated mice (p < 0.0001) . No overt signs of toxicity, such as weight loss, hunching, ruffled fur or difficulty breathing, were observed in mice treated with antibiotics. No difference in the percentage and a strong up-regulation of CD69 was observed in T cells, while both an increased recruitment and a strong up-regulation of CD69 was detectable in NK cells.